Mehr Daten, mehr Studien und immer mehr Gewissheit unter Ärzten und Wissenschaftlern, dass Long-Covid zu einer weiteren Belastungsprobe der Gesundheitssysteme wird. Trotzdem bleiben viele Rätsel. Hier eine Auswahl von Originalveröffentlichungen und Preprints (Vorveröffentlichungen ohne Begutachtung durch Peer-Review), die für unsere Recherche relevant waren:  

 

Übersicht der Weltgesundheitsorganisation (WHO) im  „Lancet“:

A clinical case definition of post-COVID-19 condition by a Delphi consensus

Zusammenfassung:

People with COVID-19 might have sustained postinfection sequelae. Known by a variety of names, including long COVID or long-haul COVID, and listed in the ICD-10 classification as post-COVID-19 condition since September, 2020, this occurrence is variable in its expression and its impact. The absence of a globally standardised and agreed-upon definition hampers progress in characterisation of its epidemiology and the development of candidate treatments. In a WHO-led Delphi process, we engaged with an international panel of 265 patients, clinicians, researchers, and WHO staff to develop a consensus definition for this condition. 14 domains and 45 items were evaluated in two rounds of the Delphi process to create a final consensus definition for adults: post-COVID-19 condition occurs in individuals with a history of probable or confirmed SARS-CoV-2 infection, usually 3 months from the onset, with symptoms that last for at least 2 months and cannot be explained by an alternative diagnosis. Common symptoms include, but are not limited to, fatigue, shortness of breath, and cognitive dysfunction, and generally have an impact on everyday functioning. Symptoms might be new onset following initial recovery from an acute COVID-19 episode or persist from the initial illness. Symptoms might also fluctuate or relapse over time. A separate definition might be applicable for children. Although the consensus definition is likely to change as knowledge increases, this common framework provides a foundation for ongoing and future studies of epidemiology, risk factors, clinical characteristics, and therapy.

 

Übersichtsartikel in „Nature Medicine“:

Post-acute COVID-19 syndrome

Zusammenfassung:
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen responsible for the coronavirus disease 2019 (COVID-19) pandemic, which has resulted in global healthcare crises and strained health resources. As the population of patients recovering from COVID-19 grows, it is paramount to establish an understanding of the healthcare issues surrounding them. COVID-19 is now recognized as a multi-organ disease with a broad spectrum of manifestations. Similarly to post-acute viral syndromes described in survivors of other virulent coronavirus epidemics, there are increasing reports of persistent and prolonged effects after acute COVID-19. Patient advocacy groups, many members of which identify themselves as long haulers, have helped contribute to the recognition of post-acute COVID-19, a syndrome characterized by persistent symptoms and/or delayed or long-term complications beyond 4 weeks from the onset of symptoms. Here, we provide a comprehensive review of the current literature on post-acute COVID-19, its pathophysiology and its organ-specific sequelae. Finally, we discuss relevant considerations for the multidisciplinary care of COVID-19 survivors and propose a framework for the identification of those at high risk for post-acute COVID-19 and their coordinated management through dedicated COVID-19 clinics.

S1- Leitlinie der medizinischen Fachgesellschaften (AWMF):

S1-Leitlinie Post-COVID/Long-COVID

Zusammenfassung:

Bei der vorliegenden S1 Leitlinie handelt es sich um einen klinisch-praktischen Leitfaden, der bei Post-/Long-COVID spezifischen Symptomen eine klinische diagnostisch-therapeutische Orientierung auf dem Boden einer sehr häufig noch begrenzten Datenlage liefern soll. In dieser Leitlinie wird insbesondere dem klinischen Versorgungsweg Rechnung getragen. Zeitnahe Aktualisierungen sollen bei Zunahme der Evidenz durchgeführt werden.

Früherkennung/Prognose von Long-Covid in „Nature Communications“:

Immunoglobulin signature predicts risk of post-acute COVID-19 syndrome

Zusammenfassung: